A system and associated methods provide healthcare entities with distributed analysis capabilities for records of a patient population. The analysis seeks to find matches between a piece of clinical knowledge introduced to a healthcare entity and data contained in the patient population records. According to one method, a service generates executable code based on the piece of clinical knowledge. Through a communication with the service, the healthcare entity makes a determination as to what extent the clinical knowledge has relevance to a patient population of the healthcare entity. Based on this determination, the healthcare entity downloads at least a portion of the executable code. Then, the records of the patient population may be analyzed by the executable code to register matches of the clinical knowledge with data contained within the records. System activity may then be initiated based on the matches registered.