用於免疫耐受誘導及免疫診斷之FVIII胜肽农业专利-农业学术服务平台

发明人:: STEINITZ, KATHARINA NORA,史坦尼兹　卡塔琳娜　诺拉,史坦尼茲　卡塔琳娜　諾拉,VAN HELDEN, PAULA MARIA WILHELMINA,凡　海登　宝拉　玛莉亚　威尔汉密娜,凡　海登　寶拉　瑪莉亞　威爾漢密娜,REIPERT, BIRGIT MARIA,瑞伯特　伯吉特　玛莉亚,瑞伯特　伯吉特　瑪莉亞,SCHWARZ, HANS-PETER,史瓦兹　汉斯　彼得,史瓦,史坦尼兹卡塔琳娜诺拉,史坦尼茲卡塔琳娜諾拉,凡海登宝拉玛莉亚威尔汉密娜,凡海登寶拉瑪莉亞威爾漢密娜,瑞伯特伯吉特玛莉亚,瑞伯特伯吉特瑪莉亞,史瓦兹汉斯彼得

摘要：: The present invention is related to peptides that can be used to reduce the immune response against FVIII or to induce tolerance to human FVIII in patients with, e.g., hemophilia A. Furthermore, the peptides can be used for immunodiagnostic purposes to detect FVIII-specific CD4+ T cells to monitor patients with hemophilia A during replacement therapy and during immune tolerance induction therapy.本發明係關於可用於減少針對FVIII之免疫反應或誘導患有例如A型血友病之患者對人類FVIII之耐受性的胜肽。此外，該等胜肽可出於免疫診斷目的用於偵測FVIII特異性CD4+ T細胞，以便在替補療法期間及在免疫耐受誘導療法期間監測患有A型血友病之患者。