Crine, Philippe,Boileau, Guy,Loisel, Thomas P.,Lemire, Isabelle,Heft, Robert,Landy, Hal,Leonard, Pierre
申请号：
AU2013203875
公开号：
AU2013203875A1
申请日:
2013.04.11
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
#$%^&*AU2013203875A120130502.pdf#####ABSTRACT (Figure 1) A bone targeted alkaline phosphatase comprising a polypeptide having the structure: Z-sALP-Y-spacer-X-Wa-V, wherein sALP is the extracellular domain of the alkaline phosphatase wherein V is absent or is an amino acid sequence of at least one amino acid X is absent or is an amino acid sequence of at least one amino acid Y is absent or is an amino acid sequence of at least one amino acid Z is absent or is an amino acid sequence of at least one amino acid and Wo is a polyaspartate or a polyglutamate wherein n = 10 to 16. Kids and methods of use thereof.1/40 4-J! 4, 00t ~I4-E W 4-JO4..JO
