KRUGER ALBERT W.,GASIECKI ALAN F.,TURNER SEAN C.,ZHANG MIN,LI HUANQIU,SHEKHAR SHASHANK,DJURIC STEVAN W.,AKRITOPOULOU-ZANZE IRINI,WELCH DENNIE S.,ZHAO HONGYU,RELO ANA-LUCIA,GANDARILLA JORGE,BRAJE WILFR
申请号：
NZ60379210
公开号：
NZ603792A
申请日:
2010.11.19
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
Disclosed herein are aryl- and heteroaryl-fused decahydropyrroloazepine, octahydro-oxepinopyrrole, octahydropyrrolothiazepine dioxide, decahydrocyclohepta[c]pyrrole, and octahydrocyclohepta[c]pyrrole derivatives of formula (I) wherein R1, R2, R3, R4, R5, A, Y1, Y2, and Y3 are as defined in the specification. The present application also relates to compositions comprising such compounds, processes for making such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds. Specific embodiments of the derivatives of formula (I) include the following: trans-2-benzyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one trans-2-benzyl-5-(naphthalen-1-ylsulfonyl)-1,2,3,3a,4,5,6,10b-octahydrobenzo[c]pyrrolo[3,4-e]azepine and cis-8-amino-2-benzyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one.
