SMITH, JENIFER L.,SEMKO, CHRISTOPHER,XU, YING-ZI,KONRADI, ANDREI, W.
申请号：
MYPI 20083293
公开号：
MY151045A
申请日:
2007.02.26
申请国别(地区):
MY
年份:
2014
代理人:
摘要：
DISCLOSED ARE COMPOUNDS, WHICH BIND VLA-4. CERTAIN OF THESE COMPOUNDS ALSO INHIBIT LEUKOCYTE ADHESION AND IN PARTICULAR, LEUKOCYTE ADHESION MEDIATED BY VLA-4. SUCH COMPOUNDS ARE USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES IN A HUMAN OR ANIMAL SUBJECT SUCH AS ASTHMA, ALZHEIMER'S DISEASE, ATHEROSCLEROSIS, AIDS DEMENTIA, DIABETES INFLAMMATORY BOWEL DISEASE, CROHN'S DISEASE, RHEUMATOID ARTHRITIS, TISSUE TRANSPLANTATION, TUMOR METASTASIS AND MYOCARDIAL ISCHEMIA. THE COMPOUNDS CAN ALSO BE, ADMINISTERED FOR THE TREATMENT OF INFLAMMATORY BRAIN DISEASES SUCH AS MULTIPLE SCLEROSIS.
