Macleod, Steven K.,Stein, Daniel J.,Hayes, James Donald,Herber, Donald L.
申请号：
AU2010229020
公开号：
AU2010229020B2
申请日:
2010.03.18
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
A process for producing a pharmaceutical suspension that comprises an active pharmaceutical ingredient ("API") having low solubility, the process comprises: (a) preparing a first solution comprising a carboxy-containing vinyl polymer and a solvent and (b) adding a compound of the API to said first solution under conditions of high- shear mixing for a time from about 5 minutes to about 5 hours, said compound being soluble in said solvent, thereby producing a suspension of particles of said API in a composition comprising said carboxy-containing vinyl polymer wherein a concentration of said API in said suspension is higher than a solubility of said API in said solvent. The present invention also provides a suspension produced by such process.
