VAN EMELEN, KRISTOF,DE BRUYN, MARCEL FRANS LEOPOLD,ALCÁZAR-VACA, MANUEL JESÚS,ANDRÉS-GIL, JOSÉ IGNACIO,FERNÁNDEZ-GADEA, FRANCISCO JAVIER,MATESANZ-BALLESTEROS, MARIA ENCARNACION,BARTOLOMÉ-NEBREDA, JOŚE
申请号：
MYPI 20012913
公开号：
MY155267A
申请日:
2001.06.20
申请国别(地区):
MY
年份:
2015
代理人:
摘要：
THE PRESENT INVENTION CONCERNS COMPOUNDS OF FORMULA (I) @@@ A STEREOCHEMICALLY ISOMERIC FORM THEREOF, AN N-OXIDE FORM THEREOF OR A PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALT THEREOF, WHEREIN -A1 =A2 -A3 =A4- IS A BIVALENT RADICAL WHEREIN ONE OR TWO OF A1 TO A4 ARE NITROGEN AND THE REMAINING A1 TO A4 ARE -CH=； -Z1-Z2- IS A BIVALENT RADICAL； -A- IS A BIVALENT RADICAL OF FORMULA -N(R6)-ALK2- OR A 5, 6 OR 7-MEMBERED SATURATED HETEROCYCLE CONTAINING ONE OR TWO NITROGEN ATOMS； R1, R2 AND R3 ARE EACH INDEPENDENTLY SELECTED FROM HYDROGEN, C1-6 ALKYL, HYDROXY, HALO AND THE LIKE； ALK1 AND ALK2 ARE OPTIONALLY SUBSTITUTED C1-6ALKANEDIYL； R5 IS A RADICAL OF FORMULA @@(D-1)(D-2)(D-3)(D-4)(D-5) @@ WHEREIN N IS 1 OR 2； P1 IS O, AND P2 IS 1 OR 2； OR P1 IS 1 OR 2, AND P2 IS 0； X IS OXYGEN , SULFUR OR=NR9； Y2 IS OXYGEN OR SULFUR； R7 IS HYDROGEN, C1-6ALKYL, C3-6CYCLOALKYL, PHENYL OR PHENYLMETHYL； R8 IS C1-6ALKYL, C3-6CYCLOALKYL PHENYL OR PHENYLMETHYL； R9 IS CYANO, C1-6ALKYL, C3-6CYCLO-ALKKYL, C1-6ALKYLOXYCARBONYL OR AMINOCARBONYL； R10 IS HYDROGEN OR C1-6 ALKYL； AND Q IS A BIVALENT RADICAL. PROCESSES FOR PREPARING SAID PRODUCT, FORMULATIONS COMPRISING SAID PRODUCTS AND THEIR USE AS A MEDICINE ARE DISCLOSED, IN PARTICULAR FOR TREATING CONDITIONS WHICH ARE RELATED TO DISTURBED FUNDIC ACCOMODATION.
