A method of treating disease states associated with mold and mycotoxin , resulting in illnesses such as Chronic Fatigue Syndrome (CFS), Gulf War Syndrome (GWS), fungal sinusitis, Rhino Sinusitis, Chronic Rhino Sinusitis (CRS), abnormalities in T and B cells, central and peripheral nervous system disorders, asthma, sarcoidosis, respiratory infections, fibromyalgia, headache, depression, autoimmune disorders, and cancer, among others, comprising delivery of a medication to the nasal passages and/or sinus cavities of a patient, wherein the medication comprises an antifungal agent.