A protection device for a syringe having a syringe body extending along a longitudinal axis comprising, at a first end an end tip including an orifice for the passage of liquid and, at a second end, an opening for the passage of a piston provided with a maneuver head; wherein the device is adapted to at least partially cover said syringe body and is made at least in part of a radioprotective material providing protection against ionizing radiation, and wherein the device is in the form of a clamp comprising two half-jaws joined together by a hinge, which clamp includes operating means configured so that said half-jaws are moveable between: a closed operative position, in which said half-jaws are assembled to form a cylinder to at least partially cover said syringe body, and an open inactive position, adapted for the introduction and extraction of said syringe body into said half-jaws.