An exemplary system includes a stimulator with a hollow lumen extending therethrough and configured to be at least partially disposed within a burr hole in a cranium of a patient, a stimulating member configured to apply a stimulus to a stimulation site within the patient, and coupling member configured to extend at least partially through the lumen and couple the stimulating member to the stimulator. Exemplary methods of applying at least one stimulus to a stimulation site within a patient include implanting a lead with a number of electrodes disposed thereon within a cavity formed by a cranium, implanting a stimulator such that the stimulator is at least partially disposed within a burr hole in the cranium, removably coupling the lead to the stimulator, and applying the at least one stimulus to a stimulation site within the cavity formed by the cranium via one or more of the electrodes.