Provided is a monoclonal antibody with a specified sequence, which binds to human CD40, comprises a heavy chain constant region which is IgG2 in which valine at position 234, glycine at position 237 and proline at position 331 are at least substituted with alanine, alanine and serine, respectively, and has an agonist activity. Further provided is a DNA which encodes the monoclonal antibody； a vector which comprises the DNA； a transformant obtainable by introducing the vector； a process for producing the monoclonal antibody using the transformant； and a pharmaceutical composition and a therapeutic agent comprising the monoclonal antibody.
