Stefan Haider,Andreas Ivens,Hanspeter Rottensteiner,Juregen Siekmann,Peter Turecek
申请号：
US14136233
公开号：
US20140121351A1
申请日:
2013.12.20
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention relates to materials and methods of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a therapeutic protein comprising contacting the oxidized carbohydrate moiety with an activated water soluble polymer under conditions that allow conjugation. More specifically, the present invention relates to the aforementioned materials and methods wherein the water soluble polymer contains an active aminooxy group and wherein an oxime or hydrazone linkage is formed between the oxidized carbohydrate moiety and the active aminooxy group on the water soluble polymer, and wherein the conjugation is carried out in the presence of a nucleophilic catalyst.
