1. A method of treating a proliferative disease in a mammal, which comprises administering to a mammal with an existing or suspected proliferative disease a therapeutically effective amount: (a) a compound with structural formula (I) or a salt, solvate, ester and / or prodrug thereof, and (b) a second agent selected from a nucleoside analog, wherein the nucleoside analog is an antimetabolite of a neoplastic cell； anthracycline and a topoisomerase inhibitor, or combinations thereof, and in which the compound of formula (I) is where X is —O— or —S—； X is —S—, —N (R) - or —O—； two of the three R are hydrogen itself； and the other R is halogen, hydroxy, optionally substituted alkyl, optionally substituted alkoxy, or Y is —O—, —S—, —N (R) - or —C (H) R—； K is —O (CH) -, -C (O), -C (O) NH (CH) -, - (CH) O-, or - (CH) O (CH) -； p is an integer from 0 to 2； each q is independently an integer from 1 to 4； R is hydrogen, halogen, nitro, cyano, optionally substituted alkyl, -OR, -SR, -N (R), -S (O) R, -C (O) R, -C ( O) OR, -C (O) N (R), -C (O) SR or -N (R) S (O) R； R is hydrogen, halogen, nitro, cyano, optionally substituted alkyl, -OR, -SR , -N (R), -S (O) R, -C (O) R, -C (O) OR, -C (O) N (R), -C (O) SR, or -N (R) S (O) R； Rpr represents hydrogen or optionally substituted alkyl； each R is independently selected from hydrogen, halogen, optionally substituted alkyl, optionally substituted cycloalkyl or optionally substituted aryl； each R is independently selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted1. Способ лечения пролиферативного заболевания у млекопитающего, который включает введение млекопитающему с имеющимся или предполагаемым пролиферативным заболеванием терапевтически эффективного количества: (a) соединения со структурной формулой (I) или его соли, сольвата, сложного эфира и/или пролекарства, и (b) второго агента, выбранного из нуклеозидного аналога, пр
