PRE-B CELL PROLIFERATION AND LYMPHOBLASTIC LEUKEMIA/HIGH-GRADE LYMPHOMA IN MIR155 TRANSGENIC MICE

• 收藏
• 分享

专利权人:

THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION

发明人:

CROCE, CARLO M.

申请号：

CA2650026

公开号：

CA2650026C

申请日:

2007.04.24

申请国别(地区):

CA

年份:

2013

代理人:

摘要：

A transgenic non-human animal, such as a mouse, has a genome that includes anucleic acid construct having at least one transcriptional regulatory sequencecapable ofdirecting expression in B cells of the animal, wherein the transcriptionalregulatory sequenceis operably linked to a nucleic acid encoding a miR155 gene product. A methodof testingthe therapeutic efficacy of an agent in treating or preventing alymphoproliferative conditionincludes assessing the effect(s) of the agent on a transgenic non-humananimal.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/