This invention relates to a toothpaste composition having nano-energy, which is characterized in that the toothpaste composition is obtained by adding several antimicrobial and activating particles in the existing general toothpaste composition production process, followed by mixing thoroughly with toothpaste material through a homogenizing agent so that the antimicrobial and activating particles are uniformly distributed in the toothpaste composition wherein the antimicrobial activating particles are formed by combing anion particles, nano-antibacterial particles and nano far infrared particles through nano-aggregation technique to achieve the health efficacies of mouth freshening, oral bacteria inhibiting and blood circulation promoting. Moreover, an invisible protective film will be formed in the surrounding area of the users teeth to further protect oral hygiene and dental health after using the product of present invention.一種具奈米能量之牙膏組合物,其特徵在於:該牙膏組合物係在一般牙膏的既有成分製作過程中,加入數抑菌活化顆粒並藉由一調勻劑與牙膏材料充分調和,使該抑菌活化顆粒能均勻分布於該牙膏組合物中,其中該抑菌活化顆粒係由奈米聚合技術將負離子顆粒、奈米抑菌顆粒及奈米遠紅外線顆粒結合為一體所形成,達到使用後口腔清新、口腔抑菌及促進血液循環等保健之功效者,且在使用本發明後,在使用者的牙齒週邊會無形的保護膜,進一步保護口腔衛生及牙齒健康。(1)‧‧‧牙膏組合物(2)‧‧‧抑菌活化顆粒(21)‧‧‧負離子顆粒(23)‧‧‧奈米抑菌顆粒(25)‧‧‧奈米遠紅外線顆粒(3)‧‧‧牙膏材料