The present invention relates to a process for the preparation of 1- (5-4-chloro-3,5-dimethoxyphenyl) furan-2-yl) -2-ethoxy- 2- 4- 4- (S) -1- (5-4-chloro-3,5-dimethoxyphenyl) furan-2-yl) -2- 2- (4- (5-methyl-1,3,4-thiadiazol-2-yl) phenyl) ethanone. The present invention also relates to a process for the preparation of (S) -1- (5-4-chloro-3,5-dimethoxyphenyl) 3,4-thiadiazol-2-yl) phenyl) ethanone crystal structure； (S) -1- (5-4-chloro-3,5-dimethoxyphenyl) furan-2-yl) -2-ethoxy- 2- 4- 4- Diazol-2-yl) phenyl) ethanone； (S) -1- (5-4-chloro-3,5-dimethoxyphenyl) furan-2-yl) -2-ethoxy- 2- 4- 4- Diazo-2-yl) phenyl) ethanone is used to inhibit (inhibit) PDE10； (S) -1- (5-4-chloro-3,5-dimethoxyphenyl) furan-2-yl) -2-ethoxy- 2- 4- 4- Diazol-2-yl) phenyl) ethanone； 2- (4-chloro-3,5-dimethoxyphenyl) furan-2-yl) -2-ethoxy- Thiadiazol-2-yl) phenyl) ethanone. <； / RTI >；본 발명은 1-(5-4-클로로-3,5-디메톡시페닐)푸란-2-일)-2-에톡시-2-(4-(5-메틸-1,3,4-티아디아졸-2-일)페닐)에타논의 순수 거울상이성질체에 관한 것이고, 구체적으로는 (S)-1-(5-4-클로로-3,5-디메톡시페닐)푸란-2-일)-2-에톡시-2-(4-(5-메틸-1,3,4-티아디아졸-2-일)페닐)에타논에 관한 것이다. 또한, 본 발명은 (S)-1-(5-4-클로로-3,5-디메톡시페닐)푸란-2-일)-2-에톡시-2-(4-(5-메틸-1,3,4-티아디아졸-2-일)페닐)에타논의 결정 구조； (S)-1-(5-4-클로로-3,5-디메톡시페닐)푸란-2-일)-2-에톡시-2-(4-(5-메틸-1,3,4-티아디아졸-2-일)페닐)에타논을 포함하는 약학 조성물； (S)-1-(5-4-클로로-3,5-디메톡시페닐)푸란-2-일)-2-에톡시-2-(4-(5-메틸-1,3,4-티아디아졸-2-일)페닐)에타논을 이용하여 PDE10을 저해(억제)하는 방법； (S)-1-(5-4-클로로-3,5-디메톡시페닐)푸란-2-일)-2-에톡시-2-(4-(5-메틸-1,3,4-티아디아졸-2-일)페닐)에타논의 제조 방법； 및 (S)-1-(5-4-클로로-3,5-디메톡시페닐)푸란-2-일)-2-에톡시-2-(4-(5-메틸-1,3,4-티아디아졸-2-일)페닐)에타논의 제조에 사용되는 특정 개별 중간체들에 관한 것이다.
