您的位置: 首页 > 农业专利 > 详情页

DERIVES AZABICYCLO (3.1.0) HEXANE UTILES COMME MODULATEURS DES RECEPTEURS D3 DE LA DOPAMINE
专利权人:
GLAXO GROUP LIMITED
发明人:
ARISTA, LUCA,BONANOMI, GIORGIO,CAPELLI, ANNA MARIA,DAMIANI, FEDERICA,DI FABIO, ROMANO,GENTILE, GABRIELLA,HAMPRECHT, DIETER,MICHELI, FABRIZIO,TARSI, LUCA,TEDESCO, GIOVANNA,TERRENI, SILVIA
申请号:
CA2557115
公开号:
CA2557115C
申请日:
2005.02.21
申请国别(地区):
CA
年份:
2012
代理人:
摘要:
The present invention relates to novel compounds of formula (I) or apharmaceutically acceptable salt thereof, wherein G is selected from a groupconsisting of: phenyl, pyridyl, benzothiazolyl, indazolyl; p is an integerranging from 0 to 5; R1 is independently selected from a group consisting of:halogen, hydroxy, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, haloC1-4alkoxy,C1-4alkanoyl; or corresponds to a group R5; R2 is hydrogen or C1-4alkyl; R3 isC1-4alkyl; R4 is hydrogen, or a phenyl group, a heterocyclyl group, a 5- or 6-membered heteroaromatic group, or a 8- to 11-membered bicyclic group, any ofwhich groups is optionally substituted by 1, 2, 3 or 4 substituents selectedfrom the group consisting of: halogen, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, C1-4alkanoyl; R5 is a moiety selected from the group consisting of:isoxazolyl, -CH2-N-pyrrolyl, 1,1-dioxido-2-isothiazolidinyl, thienyl,thiazolyl, pyridyl, 2-pyrrolidinonyl, and such a group is optionallysubstituted by one or two substituents selected from: halogen, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, C1-4alkanoyl; and when R1 is chlorine and pis 1, such R1 is not present in the ortho position with respect to the linkingbond to the rest of the molecule; and when R1 corresponds to R5, p is 1;processes for their preparation, intermediates used in these processes,pharmaceutical compositions containing them and their use in therapy, asmodulators of dopamine D3 receptors, e.g. to treat drug dependency or asantipsychotic agents.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充