PROBLEM TO BE SOLVED: To provide a novel association of heparin and polyamine, an anticoagulant comprising the association, a pharmaceutical composition containing the association, a kit for producing the association, a sustained release imparting agent, and a composition. The present invention relates to a method of manufacturing a united body. SOLUTION: [1] An aggregate of heparin and a linear or branched polyamine having three or more amino groups, [2] an anticoagulant comprising the aggregate of [1], [3] [1] A pharmaceutical composition comprising the aggregate according to [1], [4] A heparin or a salt thereof, and a linear or branched polyamine having three or more amino groups, or a salt thereof. A kit for production, [5] a sustained-release imparting agent for imparting sustained-release of heparin, comprising a linear or branched polyamine having 3 or more amino groups, or a salt thereof, and [6] A method for producing an association, which comprises mixing an aqueous solution of heparin or a salt thereof with an aqueous solution of a linear or branched polyamine having three or more amino groups or a salt thereof. [Selection diagram] Fig. 3【課題】本発明は、ヘパリンとポリアミンとの新規会合体、会合体からなる抗血液凝固剤、会合体を含む薬剤組成物、会合体の製造のためのキット、徐放性付与剤、及び会合体の製造方法等に関する。【解決手段】〔１〕ヘパリンと、3以上のアミノ基を有する直鎖状又は分岐状のポリアミンとの会合体、〔２〕〔１〕に記載の会合体からなる抗血液凝固剤、〔３〕〔１〕に記載の会合体を含む薬剤組成物、〔４〕ヘパリン又はその塩と、3以上のアミノ基を有する直鎖状若しくは分岐状のポリアミン、又はその塩とを含む、会合体の製造のためのキット、〔５〕3以上のアミノ基を有する直鎖状若しくは分岐状のポリアミン、又はその塩を含むからなる、ヘパリンの徐放性を付与するための徐放性付与剤、及び〔６〕ヘパリン又はその塩の水溶液と、3以上のアミノ基を有する直鎖状若しくは分岐状のポリアミン又はその塩の水溶液とを混合すること含む、会合体の製造方法。【選択図】図３
