The present disclosure relates to compositions and therapeutic uses of Chardonnay grape product and other grape seed products. In one embodiment, the grape seed product is used to treat or prevent joint pain or inflammation or to maintain healthy joints. The grape seed product can be the defatted portion of Chardonnay seed, such as Chardonnay pomace meal, Chardonnay pomace flour, Chardonnay seed meal, or, in some embodiments, Chardonnay seed flour or seed extract. Such products can be administered as a food or beverage.