METHODS OF INCREASING INSULIN CONTENT IN CELLS

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专利权人:

发明人:

Shimon EFRAT,Elad Sintov

申请号：

US14803270

公开号：

US20160017290A1

申请日:

2015.07.20

申请国别(地区):

US

年份:

2016

代理人:

摘要：

A method of ex-vivo increasing insulin content in progenitor cells which express Zinc Finger E-Box Binding Homeobox 1 (ZEB-1) is disclosed. The method comprises contacting the progenitor cells with an inhibitory agent directed against a polypeptide, wherein the RNA transcript encoding said polypeptide is targeted by miRNA-200c, said polypeptide being selected from the group consisting of ZEB-1, SOX-2 and SOX-6.

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