NANOPARTICULES DE LIPIDE FUSOGENIQUES ET LEUR METHODE DE FABRICATION ET UTILISATION POUR LA PRODUCTION DE CELLULE CIBLE SPECIFIQUE D'UNE PROTEINE THERAPEUTIQUE ET POUR LE TRAITEMENT D'UNE MALADIE, D'UN ETAT OUD'UN TROUBLE ASSOCIE A LA CELLULE CIBLE
Provided are nucleic acid-based expression construct for the target cell-specific production of a therapeutic protein, such as a pro-apoptotic protein, within a target cell, including a target cell that is associated with aging, disease, or other condition, such as a senescent cell or a cancer cell. Also provided are formulations and systems, including fusogenic lipid nanoparticle (LNP) formulations and systems, for the delivery of nucleic acid-based expression constructs as well as methods for making and using such constructs, formulations, and systems by the in vivo administration of a formulation, such as a fusogenic LPN formulation, comprising an expression construct for the target cell-specific production of a therapeutic protein, such as a pro-apoptotic protein, in a target cell that is associated with aging, disease, or other condition, in particular a target cell that is a senescent cell or a cancer cell.
