TUO YAN,CHENXI OUYANG,YAWEN LIU,SISHI LIU,YUAN LIU
申请号：
US16691688
公开号：
US20200086012A1
申请日:
2019.11.22
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention discloses a compound heparin anticoagulant coating liquid, a microsphere for coating and its preparation methods and applications. In the present invention, the combination of curcumin and heparin can enhance the anticoagulation functions of heparin coating, and further enhance the stability using the properties of PLA-PEG-PLA drug-loaded sustained-release microspheres, achieving the functions of anti-tissue proliferation and anti-inflammatory reactions that cannot be achieved by coatings alone such as heparin or protein, which is very important for implanted devices such as artificial blood vessels, vascular stents and vascular patches to reduce thrombosis in the human body, lower postoperative complications and improve product lifespan.
