CORIXA CORPORATION;FRED HUTCHINSON CANCER RESEARCH CENTER;UNIVERSITY OF WASHINGTON
发明人:
KOELLE, DAVID M.,CHEN, HONGBO,COREY, LAWRENCE,HOSKEN, NANCY ANN,MCGOWAN, PATRICK,FLING, STEVEN P.,POSAVAD, CHRISTINE M.
申请号：
CA2379623
公开号：
CA2379623C
申请日:
2000.09.28
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The invention provides HSV antigens that are useful for the prevention andtreatment of HSV infection. Disclosed herein are epitopes confirmed to berecognised by T-cells derived from herpetic lesions. T-cells havingspecificity for antigens of the invention have demonstrated cytotoxic activityagainst cells loaded with virally-encoded peptide epitopes, and in many cases,against cells infected with HSV. The identification of immunogenic antigensresponsible for T-cell specificity provides improved anti-viral therapeuticand prophylactic strategies. Compositions containing antigens orpolynucleotides encoding antigens of the invention provide effectivelytargeted vaccines for prevention and treatment of HSV infection.
