A method and system for determining homeostatic risk in a patient, in order to screen metabolic diseases and/or their complications and/or their treatment management, is provided. The method includes receiving, from one or more sensors coupled with the patient, galvanic skin response, bioimpedance, a photoplethysmogram (PTG), and blood pressure from the patient, executing a spectral analysis of the PTG, and calculating a homeostatic risk score based on the galvanic skin response, bioimpedance, blood pressure and PTG, and a display for displaying the homeostatic risk score.