Disclosed are methods of radioisotope infusion comprising infusing salinecomprising adiagnostic dose of a radioisotope, and delivering a pre-measured volume ofpush saline. Thedisclosed methods confer improved image quality with low background noise,higher signal tonoise ratio (SNR) and higher contrast to noise ratio (CNR), leading to betterdiagnosis and thuseliminating the need of repeating the infusion and imaging which in turnreduces exposure of apatient to radiation.