University of Leeds;Mayo Foundation for Medical Education and Research
发明人:
Jose S. Pulido,Richard G. Vile,Timothy J. Kottke,Jill M. Thompson,Rosa Maria Diaz,Christine Marie Pulido,Alan A. Melcher,Peter Selby
申请号：
US15126333
公开号：
US10441643B2
申请日:
2015.03.19
申请国别(地区):
US
年份:
2019
代理人:
摘要：
This document provides methods and materials for treating cancer. For example, methods and materials for treating cancer using combinations of antigens are provided. For example, VSV vectors designed to express a GNAQ antigen, a TYRP1 antigen, and an N-RAS antigen can be used to reduce the number of cancer cells (e.g., uveal melanoma cells) within a mammal (e.g., a human). In some cases, VSV vectors designed to express a BRAF antigen, a TOPO-11a antigen, and a YB-I antigen can be used to reduce the number of cancer cells (e.g., skin melanoma cells) within a mammal (e.g., a human). The composition can comprise less than 50 separate nucleic acid molecules.
