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Long-term storage of non-glycosylated recombinant human G-CSF
专利权人:
Sandoz AG
发明人:
Graumann, Klaus,Lerch, Helmut,Lauber, Thomas
申请号:
AU2011268944
公开号:
AU2011268944B2
申请日:
2011.06.22
申请国别(地区):
AU
年份:
2014
代理人:
摘要:
The present invention provides a method for stable long-term storage of non-glycosylated recombinant human G-CSF, wherein an aqueous acetate or glutamate buffered G-CSF composition containing the non-glycosylated recombinant human G-CSF and sorbitol is cooled to a temperature of -15°C or below to obtain a frozen G-CSF composition, which frozen composition is then stored in the frozen state and then increased in temperature to a temperature within the range of from 2°C to 8°C for a period of time adjusted to allow the composition to thaw and to obtain a liquid composition having a G-CSF content of at least 95% of the G-CSF content of the original composition.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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