ALMASSY, ROBERT,奥玛希 罗柏,奧瑪希 羅柏,SHOWALTER, RICHARD E.,修瓦特 理察Ｅ,修瓦特 理察Ｅ,THOMSON, JAMES A.,汤玛士 詹姆士Ａ,湯瑪士 詹姆士Ａ,SISSON, WES,希森 卫斯,希森 衛斯,SHIA, WEI JONG,夏伟中,夏偉中,CHEN, LI CHANG,陈立章,陳立章,LEE, YANG,李洋,李洋
申请号：
TW103109814
公开号：
TWI676683B
申请日:
2014.03.14
申请国别(地区):
TW
年份:
2019
代理人:
摘要：
The present invention relates generally to isolated to arginine deiminase (ADI) proteins that have reduced cross-reactivity with anti-ADI-PEG 20 antibodies as compared to ADI-PEG 20, but which can have functional characteristics comparable to or better than ADI-PEG 20, compositions comprising the ADI proteins, and related methods of treating arginine-dependent diseases or related diseases such as cancer.本發明大體上係關於經分離之精胺酸去亞胺酶(ADI)蛋白質(其與抗ADI-PEG 20抗體之交叉反應性比ADI-PEG 20降低，但其功能性特徵則與ADI-PEG 20類似或比其更好)、包含該等ADI蛋白質之組合物、及治療精胺酸依賴性疾病或相關疾病(諸如癌症)之相關方法。
