IL-21 (HETERODIMERIC FC-FUSED IL-21) FUSED TO IMMUNOGLOBULIN HEAVY CHAIN CONSTANT REGION HETERODIMER (HETERODIMERIC FC), AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
Korea University Research and Business Foundation;AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人:
Kyung-Mi LEE,Seon Ah LIM,Yong Sung KIM,Ye Jin KIM
申请号：
US16329817
公开号：
US20190218267A1
申请日:
2017.08.31
申请国别(地区):
US
年份:
2019
代理人:
摘要：
A heterodimeric Fc-fused protein and a pharmaceutical composition comprising the heterodimeric Fc-fused protein are disclosed. The heterodimeric Fc-fused protein comprises first and second Fc regions of an immunoglobulin heavy chain constant region (Fc) pair and in which IL-21 is bound to at least one of the N-terminus or the C-terminus of the first Fc region and/or the second Fc region, wherein CH3 domains of the first Fc region and the second Fc region are mutated such that the formation of a heterodimer is promoted.When the heterodimeric Fc-fused protein according to the present invention is used, an in vivo half-life of IL-21 included in the heterodimeric Fc-fused protein may be significantly increased.
