A refill for an electric toothbrush comprises a generally tubular structure formed by refill walls defining an interior space for accepting thereinto a coupling stem of a toothbrush handle. The refill includes a motion transmitter functionally connected to the brush head for driving it. The refill has a coupling device including a pair of mutually opposite and resiliently deformable cantilevered arms disposed in the interior space of the refill and adjacent to the refill walls. Each of the arms terminates with a coupling surface for engaging a coupling pin extending from the handle's coupling stem for secure and disengageable connection therewith.
