Industry - University Cooperation Foundation Hanyang University
发明人:
YUN, Chae Ok,LEE, Won Jai
申请号：
EP17736116
公开号：
EP3400966A4
申请日:
2017.01.05
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
The present invention relates to a pharmaceutical composition for preventing or treating a keloid disease or scars. The inventors of the present invention discovered that mortalin expression inhibition and the interaction between mortalin and p53 may be new targets for keloid treatment. In the present invention, cell death and an anti-fibrotic effect were verified by preparing a mortalin-specific shRNA (dE1-RGD/GFP/shMOT) and injecting same in a keloid spheroid. Thus, by reducing ECM expression and inducing cell death in a keloid spheroid, mortalin knockdown may be very usefully employed for keloid treatment.
