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Identification of tumor-associated cell surface antigens for diagnosis and therapy
专利权人:
发明人:
Özlem Türeci,Ugur Sahin,Gerd Helftenbein,Volker Schlüter
申请号:
US15046700
公开号:
US09910043B2
申请日:
2016.02.18
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The present invention provides agents with tumor-inhibiting activity, and which are selective for cells expressing or abnormally expressing a tumor-associated antigen. Said tumor-associated antigen has a nucleotide sequence selected from the group consisting of: (a) a nucleotide sequence selected from the specific sequences set forth herein, or a 6-50 contiguous nucleotide residue portion thereof (b) a nucleotide sequence of a nucleic acid which hybridizes with a nucleic acid having the nucleotide sequence of (a) under stringent conditions (c) a nucleotide sequence which is degenerate with respect to the nucleotide sequence of (a) or (b) and (d) a nucleotide sequence which is complementary to the nucleotide sequence of (a), (b) or (c). Pharmaceutical compositions and kits comprising the agents are also provided, as well as methods treating, diagnosing or monitoring a disease characterized by expression or abnormal expression of the tumor-associated antigen.
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