Christophe Arbogast,Philippe Bussat,Hong (Helen) Fan,Sudha Khurana,Karen E. Linder,Edmund R. Marinelli,Palaniappa Nanjappan,Adrian D. Nunn,Radhakrishna K. Pillai,Sibylle Pochon,Kondareddiar Ramalingam
申请号：
US14085645
公开号：
US09408926B2
申请日:
2013.11.20
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention provides polypeptides, peptide dimers, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD<；1 μM), and dimer and multimeric constructs comprising these polypeptides, particularly contrast agents. Also provided are methods for monitoring and evaluating the therapeutic effectiveness of treatment protocols for diseases associated with angiogenesis or endothelial cell hyperproliferation, such as cancer, using contrast agents of the invention.
