COMBINATION OF AN INHIBITOR OF HMG-COA REDUCTASE AND AN INHIBITOR OF PHARMSYL PYROPHOSPHATASE SYNTHASE FOR THE TREATMENT OF DISEASES RELATED TO PERSISTENCE AND / OR ACCUMULATION OF PRENYLATED PROTEINS
Assistance Publique Hôpitaux de Marseille;Université d'Aix-Marseille;Association Francaise Contre Les Myopathies (AFM);Université dAix-Marseille;Universidad de Oviedo
发明人:
Levy, Nicolas,Cau, Pierre,Lopez-Otin, Carlos
申请号：
DK15160222
公开号：
DK2921172T3
申请日:
2007.07.05
申请国别(地区):
DK
年份:
2018
代理人:
摘要：
The invention relates to the use of a hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor and of a farnesyl-pyrophosphate synthase inhibitor, or of one of their associated physiologically acceptable salts, in the preparation of a composition, particularly a pharmaceutical composition, for use in the treatment of human or animal, pathological or nonpathological situations related to the accumulation and/or the persistence of prenylated proteins in cells, such as during progeria (Hutchinson-Gilford syndrome), restrictive dermopathy or physiological aging.
