GILES-KOMAR, JILL,金吉儿,金吉兒,HEAVNER, GEORGE,汉乔治,漢喬治,KNIGHT, DAVID M.,奈大卫,奈大衛,LUO, JINQUAN,罗金泉,羅金泉,PERITT, DAVID,皮瑞特,SCALLON, BERNARD,史克隆,SHEALY, DAVID,薛艾利
申请号：
TW094145355
公开号：
TWI406943B
申请日:
2005.12.20
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
An anti－IL－12 antibody that binds to a portion of the IL－12 protein corresponding to at least one amino acid residue selected from the group consisting of residues 15, l7－21, 23, 40－43, 45－47, 54－56 and 58－62 of the amino acid sequence of the p40 subunit of IL－12, including isolated nucleic acids that encode at least one anti－IL－12 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.本發明乃有關與對應於選自由IL－12之p40次單元胺基酸序列殘基15、17－21、23、40－43、45－47、54－56與58－62組成組群之至少一個胺基酸殘基之部分IL－12蛋白結合之抗－IL－12抗體，包括編碼至少一種抗－IL－12抗體之單離核酸、載體、宿主細胞、基因轉殖動物或植物，及其製造方法與應用於診斷及/或治療組成物、方法及裝置之用途。
