THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIO
发明人:
RING, AARON MICHAEL AM,GARCIA, KENAN CHRISTOPHER KC,WEISKOPF, KIPP ANDREW KA,LEVIN, ARON M. AM,WEISSMAN, IRVING L. IL,‧林,‧加西亞,‧魏斯可夫,‧萊文,‧威斯曼
申请号：
HK15102460.0
公开号：
HK1201757A
申请日:
2015.03.10
申请国别(地区):
HK
年份:
2015
代理人:
摘要：
High affinity SIRP-α reagent are provided, which (i) comprise at least one amino acid change relative to the wild-type protein； and (ii) have an increased affinity for CD47 relative to the wild-type protein. Compositions and methods are provided for modulating phagocytosis in a mammal by administering a therapeutic dose of a pharmaceutical composition comprising a high affinity SIRPα reagent, which blocks the physiological binding interaction between SIRPα and its ligand CD47.
