Prodrugs of substituted triazole derivatives and uses thereof

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专利权人:

바이엘 악티엔게젤샤프트;바이엘 파마 악티엔게젤샤프트

发明人:

콜린-크뢰펠린, 마리-피에르,콜코프, 페터,노이바우어, 토마스,퓌르스트너, 한탈,포오크, 엘리자베트,비트버, 마티아스, 베아트,슈메크, 카르슈텐,바스나이레, 피에르,시르머, 하이코,체르네카, 하나,드뢰프너, 카롤리네,티넬, 한나,부흐뮐러, 안야,몬드리츠키, 토마스,크레치머, 악셀,루스티히, 클레멘스,프리케, 로베르트,레빌라인, 구일라우메,크렌츠, 우르술라

申请号：

KR1020207014412

公开号：

KR1020200069361A

申请日:

2018.10.17

申请国别(地区):

KR

年份:

2020

代理人:

摘要：

The present invention is 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro -1H-1,2,4-triazol-1-yl}methyl)-1-[3-(trifluoromethyl)-pyridin-2-yl]-1H-1,2,4-triazole-5 -Carboxamide, 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5- Dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[2-(trifluoromethyl)phenyl]-1H-1,2,4-triazole-5-carbox Amide and 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro- Prodrug of 1H-1,2,4-triazol-1-yl}methyl)-1-(3-chloropyridin-2-yl)-1H-1,2,4-triazole-5-carboxamide , Methods of making such compounds, pharmaceutical compositions containing such compounds, and the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of kidney and cardiovascular diseases.본 발명은 3-({3-(4-클로로페닐)-5-옥소-4-[(2S)-3,3,3-트리플루오로-2-히드록시프로필]-4,5-디히드로-1H-1,2,4-트리아졸-1-일}메틸)-1-[3-(트리플루오로메틸)-피리딘-2-일]-1H-1,2,4-트리아졸-5-카르복스아미드, 3-({3-(4-클로로페닐)-5-옥소-4-[(2S)-3,3,3-트리플루오로-2-히드록시프로필]-4,5-디히드로-1H-1,2,4-트리아졸-1-일}메틸)-1-[2-(트리플루오로메틸)페닐]-1H-1,2,4-트리아졸-5-카르복스아미드 및 3-({3-(4-클로로페닐)-5-옥소-4-[(2S)-3,3,3-트리플루오로-2-히드록시프로필]-4,5-디히드로-1H-1,2,4-트리아졸-1-일}메틸)-1-(3-클로로피리딘-2-일)-1H-1,2,4-트리아졸-5-카르복스아미드의 전구약물, 이러한 화합물의 제조 방법, 이러한 화합물을 함유하는 제약 조성물, 및 질환의 치료 및/또는 예방, 특히 신장 질환 및 심혈관 질환의 치료 및/또는 예방을 위한 이러한 화합물 또는 조성물의 용도에 관한 것이다.

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