The present invention relates to a method for the prevention or treatment of diseases such as pharmaceuticals, pharmaceutical compositions or foods, lifestyle-related diseases, and the like comprising Met (M) or an analog thereof and a dipeptide containing His (H) or an analog thereof as an active ingredient. Provide use.本発明は、Met(M)またはそのアナログとHis(H)またはそのアナログを含むジペプチドを有効成分とする医薬、医薬組成物または食品、生活習慣病などの疾患の予防又は治療のための方法及び使用を提供する。