DGOEY DAVID A.,KATI WARREN M.,HUTCHINS CHARLES W.,DONNER PAMELA L.,KRUEGER ALLAN C.,RANDOLPH JOHN T.,MOTTER CHRISTOPHER E.,NELSON LISSA T.,PATEL SACHIN V.,MATULENKO MARK. A.,KEDDY RYAN G.,JINKERSON TA
申请号：
ARP110103777
公开号：
AR083398A1
申请日:
2011.10.12
申请国别(地区):
AR
年份:
2013
代理人:
摘要：
3. The effective compounds that inhibit the replication of hepatitis C virus (ldqoe； HCV rdqoe；)；The processing of these compounds, the compounds containing them, and the method of treating HCB infection with these compounds: a compound called formula (1),Or a pharmaceutically acceptable salt, where x is a carbohydrate of c3-12 or a non carbohydrate of 3-12, which can be replaced by one or more RA or RF； L1 and L2 are independently selected links； or C1-6 tar, c2-6 tar, or c2-6 tar, Each of them can be replaced by one or more RLS； L3 is an o-ls-k-ls rsqoe link； -,If you are already registered, please log in first.- yes.-N (RB) --C (O) --S (O) 2--S (O) --OS (O) --O (o) 2---S (O) 2O--Yes, it is-That's it.-OC (o)..-O (o) or--C (O) N (RB) --N (RB) C (O) --N (RB) C (o) or--OC (O) N (RB) --N (RB) S (O) --N (RB) S (O) 2--S (O) N (RB) --S (O) 2N (RB) --C (O) N (RB) C (O) --N (RB) C (O) N (RB 26rsquo) --N (RB) SO2N (RB 26rsquo) -o -N (RB) S (O) N (RB 26rsquo) -A and B are independent c3-12 type carbohydrates or 3-12 type non orthogonal carbohydrates, which can be replaced by one or more RA alone； D is c3-12 type carbohydrates or 3-12 type non orthogonal carbohydrates, which can be replaced by one or more RA； D is c3-12 type carbohydrates or 3-12 type non orthogonal carbohydrates. And 12 members, substituted by J, optionally substituted by one or more RA, j as carbohydrate c3-12, or substituted by one or more RA, or j as sF5, or D as hydrogen or RA； selected from T RSQE； C (r1r2) n (R5) - t-rd-t RSQE； - C (r3r4) C (r6r7) - t-rd, - lk-rd, o-lke；R1 and R2 are independent RC, R5 is RB； or R1 is RC, R2 and R5, together with the atoms to which they are attached, constitute a heterocycle of 3 to 12 members, which can be optionally replaced by one or more RA； R3, R4, R6 and R7 are independent RC； O R3 and R6 are independent RC. R4 and R7, together with the atoms they connect, form a carbohydrate or non carbohydrate of 3 to 12 members, which can be replaced by one or more RA.
