Various types of lactic acid bacteria were cultured in the presence of a purine, the amount of the purine consumed and the amount of purine degradation products produced were, measured, and several lactic acid bacteria showing remarkable purme-decomposing ability were selected. Lactic acid bacteria that were assessed to have high purine-decomposing ability according to the above-mentioned selection were orally administered to rats reared on purine-containing feed, the general status and serum uric acid level of the rats were measured, and the effect of lactic acid bacteria administration on serum uric acid levels was examined. As a result, lactic acid bacteria that significantly suppress the increase of serum uric acid levels, Lactobacillus gasseri OLL2959 and Lactobacillus oris OLL2779, were found.푸린체(purines) 존재하에서 각종 유산균을 배양하고, 그 푸린체의 소비량 및 그 푸린체 분해물의 생산량을 측정하여, 푸린체 분해능이 현저한 복수의 유산균을 선발하였다. 상기 선발에 의해 푸린체 분해능이 높다고 판단된 유산균을, 푸린체 함유 사료로 사육한 랫트에 경구투여하고, 당해 랫트의 일반상태 및 혈청 요산치를 측정하여, 유산균 투여에 따른 혈청 요산치로의 영향을 검토하였다. 그 결과, 혈청 요산치의 상승을 유의하게 억제하는 유산균:Lactobacillus gasseri OLL2959 및 Lactobacillus oris OLL2779를 발견하였다.
