1. A compound of formula I, a stereoisomer, a cis-trans isomer, a tautomer thereof or a mixture thereof or a pharmaceutically acceptable salt thereof, a solvate thereof or a prodrug thereof, wherein R is selected from the group consisting of substituted or unsubstituted alkylacylamino, substituted or unsubstituted alkenylacylamino, substituted or unsubstituted alkynylacylamino, substituted or unsubstituted arylacylamino, substituted or unsubstituted amino and substituted or unsubstituted alkoxy and R and R are each independently selected from the group consisting of hydrogen, substituted or unsubstituted ar alkyl, substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl or R and R, together with the nitrogen atom to which they are attached, form a substituted or unsubstituted heterocyclyl and R & lt 1 & gt is a substituted or unsubstituted heterocyclyl or substituted or unsubstituted heteroaryl. A compound according to claim 1, wherein R4 is tetrahydrofuranyl. The compound according to claim 1, its stereoisomer, its cis-trans isomer, its tautomer or a mixture thereof, or a pharmaceutically acceptable salt thereof, a solvate thereof or a prodrug thereof, wherein R is selected from the group consisting of C 1 -C 6 alkylamino, C 1 -C 6 -alkenylacylamino, , C-Carylacylamino, Ci-6alkyl, substituted amino, and Ci-C2-alkoxy iodine from R 1 and R 4 is H, while the other is selected from the group consisting of C 1 -C 4 -alkyl, substituted or unsubstituted C 1 -Caryl and substituted or unsubstituted C-C heteroaryl, wherein the substituent on aryl is selected from the group consisting of C 1 -C 6 alkynyl, C1-C4 aralkyloxy, C1-C6-heteroaralkyloxy, C-Caryloxy and C-heteroaryloxy, and the heteroaryl substituent is selected from the group consisting of C-Ci-Calkyl, C-Carylacylamino, C-Carylsulphonylamino, C-Cget where R4 is tetrahydrofuranyl. The compound according to claim 1, its stereoisomer, its cis-trans isomer, its tautomer or a mixture thereof, or a pha
