A method for delivering glucose and insulin to a subject to improve carbohydrate metabolism. It is desirable to improve liver storage of glycogen, and in general to reduce excess fatty tissue in the liver. The method delivers a large amount of glucose accompanied by a series of bursts of insulin to the subject over a period of time. The amount of insulin in each burst, the interval between bursts and the amount of time to deliver each burst to the subject are selected so that the cellular processing of glucose is improved in the subject. The glucose is delivered in dose portions over an extended period of hours, typically providing a roughly even rate of glucose input during the insulin administration. Treatments are repeated over multiple days. For most subjects, an improvement in resting amount of carbohydrate metabolism is seen.
