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SUBSTITUTED AROMATIC COMPOUNDS AND RELATED METHOD FOR THE TREATMENT OF FIBROSIS
专利权人:
PROMETIC BIOSCIENCES INC.
发明人:
ZACHARIE, BOULOS,ABBOTT, SHAUN,GAGNON, LYNE,LAURIN, PIERRE,GROUIX, BRIGITTE
申请号:
PH12015502011
公开号:
PH12015502011A1
申请日:
2015.09.09
申请国别(地区):
PH
年份:
2016
代理人:
摘要:
The present invention relates to compounds of: or a pharmaceutically acceptable salt thereof, wherein A is C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(0)-(CH2)n-CH3 or CH(OH)-(CH2)n-CH3 wherein n is 3 or 4 R1 is H, F or OH R2 is C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(0)-(CH2)n-CH3 or CH(OH)-(CH2)n-CH3 wherein n is 3 or 4 R3 is H, F, OH or CH2Ph R4 is H, F or OH Q is 1 ) (CH2)mC(0)OH wherein m is 1 or 2, 2) CH(CH3)C(0)OH, 3) C(CH3)2C(0)OH, 4) CH(F)-C(0)OH, 5) CF2-C(0)OH, or 6) C(0)-C(0)OH and compositions comprising the same and the method using the same for the prevention or treatment of various fibrotic diseases and conditions in subjects, including pulmonary fibrosis, liver fibrosis, skin fibrosis, renal fibrosis, pancreas fibrosis, systemic sclerosis, cardiac fibrosis or macular degeneration.
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