An aircraft seat assembly for aircraft passengers having restricted mobility comprises a seat base assembly that comprises a first carrier device and a first fastening means. The aircraft seat assembly further comprises a wheelchair sub-frame, a second carrier device and a second fastening means. The dimensions of the wheelchair sub-frame are adapted to the dimensions of aisles provided in the aircraft cabin. Finally, the aircraft seat assembly comprises a seat which comprises a fastening means that is complementary to the first fastening means of the seat base assembly and to the second fastening means of the wheelchair sub-frame.