Ramot at Tel-Aviv University Ltd.;Mor Research Applications Ltd.
发明人:
Ruth Shalgi,Dana Chuderland,Hadas Bar-Joseph,Keren Goldberg,Irit Ben-Aharon,Salomon M. Stemmer
申请号：
US15129007
公开号：
US10130682B2
申请日:
2015.03.30
申请国别(地区):
US
年份:
2018
代理人:
摘要：
A method of treating or preventing gonadal or uterine toxicity induced by an agent in a subject is provided. Accordingly there is provided a method comprising administering to a subject a therapeutically effective amount of pigment epithelium-derived factor (PEDF), thereby treating or preventing the gonadal toxicity induced by the agent. Also provided is, a method comprising determining gonadal function in a subject； and administering to the subject a therapeutically effective amount of PEDF, thereby treating or preventing the gonadal toxicity induced by the agent. Also provided is a PEDF for use in the treatment or prevention of gonadal toxicity induced by an agent in a subject. Also provided are cell culture, a medium, a kit and method for improving oocyte quality ex-vivo.
