The present invention relates to compounds of Formula (I): Wherein variables are as defined above. The compounds have apoptosis signal-regulating kinase (“ASK1”) inhibitory activity, and are thus useful in the treatment of ASK1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases, diabetes, diabetic nephropathy, cardio-renal diseases, including kidney disease, fibrotic diseases, respiratory diseases, COPD, idiopathic pulmonary fibrosis, acute lung injury, acute and chronic liver diseases, and neurodegenerative diseases.本發明關於式(I)化合物：其中變數如上述所定義。該等化合物具有細胞凋亡訊息調節激酶(“ASK1”)抑制活性，且因此可用於治療ASK1介導的病況，包括自體免疫疾病、發炎性疾病、心血管疾病、糖尿病、糖尿病腎病變、心腎疾病(包括腎臟病)、纖維化疾病、呼吸道疾病、COPD、特發性肺纖維化、急性肺損傷、急性和慢性肝臟疾病、及神經退化性疾病。
