CHILCOTE, TAMIE J.,GOLDSTEIN, JASON,ANDERSON, JOHN P.,WALKER, DONALD
申请号：
CA2584512
公开号：
CA2584512C
申请日:
2005.10.19
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The application identifies novel fragments of alpha-synuclein in patients withLewy Body Disease (LBD) and transgenic animal models thereof. These diseasesare characterized by aggregations of alpha-synuclein. The fragments have atruncated C-terminus relative to full-length alpha-synuclein. Some fragmentsare characterized by a molecular weight of about 12 kDa as determined by SDSgel electrophoresis in tricine buffer and a truncation of at least tencontiguous amino acids from the C-terminus of natural alpha-synuclein. Thesite of cleavage preferably occurs after residue 117 and before residue 126 ofnatural alpha-synuclein. The identification of these novel fragments of alpha-synuclein has a number of application in for example, drug discovery,diagnostics, therapeutics, and transgenic animals.
