An embodiment of a segmentation solution for use in diagnostic imaging applications is proposed. A corresponding embodiment of a data-processing segmentation method comprises: providing a representation over a non-zero analysis time period of a body-part being perfused with a contrast agent, the representation comprising, for each location of a set of locations of the body-part, an indication of a response over the analysis time period of the location to an interrogation signal； calculating, for each selected location of a set of selected locations, the value of at least one statistical parameter of a statistical distribution of the response over the analysis time period of the selected location, the set of selected locations comprising all the locations or a part thereof； and segmenting the selected locations according to a comparison between the values of said at least one statistical parameter for the selected locations with at least one segmentation threshold.
