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COMBINATIONS AND METHODS OF INTRODUCING THERAPEUTIC MEDICINES AND COMBINED THERAPY
专利权人:
АБРАКСИС БАЙОСАЙЕНС; ЭлЭлСи (US)
发明人:
ДИСЭЙ Нейл П. (US),СООН-ШИОНГ Патрик (US)
申请号:
RU2012106620/15
公开号:
RU2012106620A
申请日:
2012.02.22
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
1. A method of treating a proliferative disease in an individual, comprising administering to the individual an effective amount of a composition comprising nanoparticles comprising rapamycin and a carrier protein. The method of claim 1, wherein the proliferative disease is cancer. The method of claim 2, wherein the proliferative disease is colon cancer. The method of claim 1, wherein the composition comprises nanoparticles comprising rapamycin coated with a carrier protein. The method according to claim 1, where the average diameter of the nanoparticles in the composition is not more than approximately 200 nm. The method according to claim 5, where the average diameter of the nanoparticles in the composition is not more than approximately 150 nm. The method of claim 1, wherein the carrier protein is albumin. The method of claim 7, wherein the albumin is human serum albumin. A method of treating a proliferative disease in an individual, comprising administering to the individual a composition comprising nanoparticles comprising a taxane and a carrier protein, wherein the composition is administered weekly and the dose of taxane in the composition is from about 100 mg / md to about 150 mg / m. 10. The method of claim 9, wherein the dose of taxane in the composition is about 150 mg / m. The method of claim 9, wherein the composition is administered over three of four weeks in a four-week cycle. The method of claim 9, wherein the composition comprises nanoparticles comprising a taxane coated with a carrier protein. The method of claim 9, wherein the carrier protein is albumin. The method of claim 13, wherein the albumin is human serum albumin. The method of claim 9, wherein the average diameter of the nanoparticles in the composition is not more than about 200 nm. The method according to1. Способ лечения пролиферативного заболевания у индивидуума, включающий введение индивидууму эффективного количества композиции, содержащей наночастицы, включающие рапамицин и белок-но
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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