Cherie Stabler,Kerim Gattas-Asfura,Kristina Finn,Camillo Ricordi,Hernan R Rengifo
申请号：
US12633270
公开号：
US08728520B2
申请日:
2009.12.08
申请国别(地区):
US
年份:
2014
代理人:
摘要：
A biocompatible capsule comprising a biological material encapsulated by a covalently stabilized coating and a method of making the same are disclosed. The biological material can be a material selected from the group consisting of cells, such as islets of Langerhans, pharmaceuticals, and biological agents. The coating can be formed by reacting an alginate-[polyalkylene glycol (PAG)-X1]n, and a multi-functional PAG-X2, to form covalent bonds, wherein n is an integer greater than 0, a first one of X1 and X2 is N3, and a second one of X1 and X2 is selected from the group consisting of:wherein R1=CH3, CH2CH3, CH(CH3)2,R2=N(CH3)2, OCH3, OH, CH3, H, F, Cl, Br or NO2, and R3=OCH3, CH3, H, F, Cl or NO2.
